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Vertical Infection: What have we learned so far?

Intrauterine vertical transmission of SARS-COV2: What we know so far?  Wang C et al.  (ISUOG Apr 7, 20; doi: 10.1002 / uog.22045) Compiled by: Dr.  Tutku Taşkınoğlu (Düzen Laboratories Group)


Conclusion: New studies are needed to clarify whether there is vertical transmission: Cohort studies in which pregnant women with COVID-19 infection are evaluated in terms of structural malformation, fetal development and retardation in the first and second trimester.


  • Cord blood, placental tissue, amniotic fluid, and amnio-chorionic interface swab samples and a pharyngeal swab sample from the newborn should be obtained and examined immediately after birth from women with COVID-19. If possible, placental samples of pregnant women with miscarriage COVID19 infection should also be examined. Serological tests can be important.  While the PCR test is negative in biological samples taken immediately after birth, if the IgM and IgG antibodies are positive in the newborn, longitidunal monitoring of the baby’s IgG antibody levels is required.  If the baby’s IgG antibodies become negative within six months, the possibility of intrauterine infection can be excluded.


If the IgG antibodies in the baby persist for up to eighteen months or longer, the diagnosis of congenital infection can be confirmed.

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